Performance of a new coaxial ion–molecule reaction region for low-pressure chemical ionization mass spectrometry with reduced instrument wall interactions

Palm, Brett B.; Liu, Xiaoxi; Jimenez, Jose L.; Thornton, Joel A.

doi:https://doi.org/10.5194/amt-12-5829-2019

Articles | Volume 12, issue 11

https://doi.org/10.5194/amt-12-5829-2019

© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/amt-12-5829-2019

© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 12, issue 11

Research article

|

07 Nov 2019

Research article |

| 07 Nov 2019

Performance of a new coaxial ion–molecule reaction region for low-pressure chemical ionization mass spectrometry with reduced instrument wall interactions

Brett B. Palm, Xiaoxi Liu, Jose L. Jimenez, and Joel A. Thornton

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Final revised paper (published on 07 Nov 2019)
Supplement to the final revised paper
Preprint (discussion started on 01 Jul 2019)
Supplement to the preprint

Interactive discussion

Status: closed

AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment

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- Supplement

RC1: 'review of Palm et al.', Anonymous Referee #1, 16 Aug 2019
- AC1: 'Response to Reviewer #1', Brett B. Palm, 09 Oct 2019
RC2: 'Comments for Palm et al.', Anonymous Referee #2, 24 Sep 2019
- AC2: 'Response to Reviewer #2', Brett B. Palm, 09 Oct 2019

Peer-review completion

AR: Author's response | RR: Referee report | ED: Editor decision

AR by Brett B. Palm on behalf of the Authors (09 Oct 2019) Author's response Manuscript

ED: Publish as is (11 Oct 2019) by Hendrik Fuchs

AR by Brett B. Palm on behalf of the Authors (11 Oct 2019)

Short summary

We introduce a coaxial, low-pressure ion–molecule reaction (IMR) region for iodide-adduct chemical ionization mass spectrometry, designed to decrease the effects of IMR wall interactions with organic/inorganic gases. This IMR has 3–10 times shorter delay times than previous IMRs. We introduce a conceptual framework for understanding and subtracting the background signal due to analyte molecules interacting with IMR walls. This framework can be applied to other tubing and instrument systems.