We present a methane flux rate retrieval methodology using the Sentinel-2 mission, validating the algorithm for different scenes and plumes. The detection limit is 1000–2000 kg h⁻¹ for homogeneous scenes and temporally invariant surfaces and above 5000 kg h⁻¹ for heterogeneous ones. Dominant quantification errors are wind-related or plume mask-related. For heterogeneous scenes, the surface structure underlying the methane plume can become a dominant source of uncertainty.