Articles | Volume 15, issue 24
Research article
22 Dec 2022
Research article |  | 22 Dec 2022

Chemical ionization mass spectrometry utilizing ammonium ions (NH4+ CIMS) for measurements of organic compounds in the atmosphere

Lu Xu, Matthew M. Coggon, Chelsea E. Stockwell, Jessica B. Gilman, Michael A. Robinson, Martin Breitenlechner, Aaron Lamplugh, John D. Crounse, Paul O. Wennberg, J. Andrew Neuman, Gordon A. Novak, Patrick R. Veres, Steven S. Brown, and Carsten Warneke


Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on amt-2022-228', Anonymous Referee #1, 03 Sep 2022
    • AC1: 'Reply on RC1', Lu Xu, 19 Oct 2022
  • RC2: 'Comment on amt-2022-228', Anonymous Referee #2, 19 Sep 2022
    • AC2: 'Reply on RC2', Lu Xu, 19 Oct 2022

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision | EF: Editorial file upload
AR by Lu Xu on behalf of the Authors (04 Nov 2022)  Author's response   Author's tracked changes   Manuscript 
ED: Publish as is (19 Nov 2022) by Anna Novelli
AR by Lu Xu on behalf of the Authors (21 Nov 2022)
Short summary
We describe the development and operation of a chemical ionization mass spectrometer using an ammonium–water cluster (NH4+·H2O) as a reagent ion. NH4+·H2O is a highly versatile reagent ion for measurements of a wide range of oxygenated organic compounds. The major product ion is the cluster with NH4+ produced via ligand-switching reactions. The instrumental sensitivities of analytes depend on the binding energy of the analyte–NH4+ cluster; sensitivities can be estimated using voltage scanning.