Articles | Volume 15, issue 24
https://doi.org/10.5194/amt-15-7353-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/amt-15-7353-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Research article
| 
22 Dec 2022
Research article |
| 22 Dec 2022
| 22 Dec 2022
Chemical ionization mass spectrometry utilizing ammonium ions (NH4+ CIMS) for measurements of organic compounds in the atmosphere
Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, USA
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Matthew M. Coggon
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Chelsea E. Stockwell
Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, USA
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Jessica B. Gilman
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Michael A. Robinson
Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, USA
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Department of Chemistry, University of Colorado Boulder, Boulder, CO, USA
Martin Breitenlechner
Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, USA
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Aaron Lamplugh
Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, USA
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
now at: Institute of Behavioral Science, University of Colorado Boulder, Boulder, Colorado, USA
John D. Crounse
Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA, USA
Paul O. Wennberg
Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA, USA
Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA
J. Andrew Neuman
Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, USA
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Gordon A. Novak
Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, CO, USA
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Patrick R. Veres
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Steven S. Brown
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
Department of Chemistry, University of Colorado Boulder, Boulder, CO, USA
Carsten Warneke
CORRESPONDING AUTHOR
NOAA Chemical Sciences Laboratory, Boulder, CO, USA
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Cited
20 citations as recorded by crossref.
- Deployment and evaluation of an NH4+∕ H3O+ reagent ion switching chemical ionization mass spectrometer for the detection of reduced and oxygenated gas-phase organic compounds C. Zang & M. Willis 10.5194/amt-18-17-2025
- Evaluation of a reduced-pressure chemical ion reactor utilizing adduct ionization for the detection of gaseous organic and inorganic species M. Riva et al. 10.5194/amt-17-5887-2024
- Sensitive determination of volatile nitrosamines with ambient pressure ammonium-adduct ionization mass spectrometry L. Duan et al. 10.1007/s00216-024-05580-7
- Cl2− chemical ionization mass spectrometry (Cl2-CIMS) for the measurement of acyl peroxy radicals T. Berg et al. 10.1039/D5EA00043B
- Advances in an OH reactivity instrument for airborne field measurements H. Fuchs et al. 10.5194/amt-18-881-2025
- Identifying and correcting interferences to PTR-ToF-MS measurements of isoprene and other urban volatile organic compounds M. Coggon et al. 10.5194/amt-17-801-2024
- Decomposition of Clusters of Oxygenated Compounds with NO3– by Applying Voltage Scanning to Chemical Ionization Mass Spectrometry in Steady-State Experiments H. Wang et al. 10.1021/acs.estlett.4c00276
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- Recent advances in mass spectrometry techniques for atmospheric chemistry research on molecular‐level W. Zhang et al. 10.1002/mas.21857
- Photodegradation of naphthalene-derived particle oxidation products F. Sari Doré et al. 10.1039/D4EA00125G
- Quantitative Determination of Volatile N-Nitrosamines in Meat Products Using Gas Chromatography Coupled to an Ion Mobility Spectrometer with an Ammonia Dopant C. Wang et al. 10.1021/acs.jafc.4c07826
- Optimizing the iodide-adduct chemical ionization mass spectrometry (CIMS) quantitative method for toluene oxidation intermediates: experimental insights into functional-group differences M. Song et al. 10.5194/amt-17-5113-2024
- Online Calibration of a Chemical Ionization Mass Spectrometer for Multifunctional Biogenic Organic Nitrates M. Robinson et al. 10.1021/acsestair.4c00056
- Analysis of Fentanyl and Fentanyl Analogs Using Atmospheric Pressure Chemical Ionization Gas Chromatography–Mass Spectrometry (APCI-GC-MS) K. Reyes Monroy et al. 10.1021/jasms.4c00455
- Extending the Range of Detectable Trace Species with the Fast Polarity Switching of Chemical Ionization Orbitrap Mass Spectrometry R. Cai et al. 10.1021/acs.analchem.4c00650
- Effects of Relative Humidity on Time-Resolved Molecular Characterization of Secondary Organic Aerosols from the OH-Initiated Oxidation of Cresol in the Presence of NOx C. Carstens et al. 10.1021/acs.est.4c08215
- Constraining Gas Phase Yields and Reactive Uptake Coefficients of Oxidation Products from the Hydroxyl Radical-Isoprene Reaction onto Acidic Particles by Vocus Ammonia-Adduct Chemical Ionization Mass Spectrometry (Vocus NH4+ CIMS) J. Zhao et al. 10.1021/acsestair.4c00367
- Measuring pesticides in the atmosphere: current status, emerging trends and future perspectives M. Brüggemann et al. 10.1186/s12302-024-00870-4
- Rapid screening of volatile chemicals in surface water samples from the East Palestine, Ohio chemical disaster site with proton transfer reaction mass spectrometry J. Jiang et al. 10.1016/j.scitotenv.2024.176056
- Ammonium adduct chemical ionization to investigate anthropogenic oxygenated gas-phase organic compounds in urban air P. Khare et al. 10.5194/acp-22-14377-2022
19 citations as recorded by crossref.
- Deployment and evaluation of an NH4+∕ H3O+ reagent ion switching chemical ionization mass spectrometer for the detection of reduced and oxygenated gas-phase organic compounds C. Zang & M. Willis 10.5194/amt-18-17-2025
- Evaluation of a reduced-pressure chemical ion reactor utilizing adduct ionization for the detection of gaseous organic and inorganic species M. Riva et al. 10.5194/amt-17-5887-2024
- Sensitive determination of volatile nitrosamines with ambient pressure ammonium-adduct ionization mass spectrometry L. Duan et al. 10.1007/s00216-024-05580-7
- Cl2− chemical ionization mass spectrometry (Cl2-CIMS) for the measurement of acyl peroxy radicals T. Berg et al. 10.1039/D5EA00043B
- Advances in an OH reactivity instrument for airborne field measurements H. Fuchs et al. 10.5194/amt-18-881-2025
- Identifying and correcting interferences to PTR-ToF-MS measurements of isoprene and other urban volatile organic compounds M. Coggon et al. 10.5194/amt-17-801-2024
- Decomposition of Clusters of Oxygenated Compounds with NO3– by Applying Voltage Scanning to Chemical Ionization Mass Spectrometry in Steady-State Experiments H. Wang et al. 10.1021/acs.estlett.4c00276
- Product ion distributions using H3O+ proton-transfer-reaction time-of-flight mass spectrometry (PTR-ToF-MS): mechanisms, transmission effects, and instrument-to-instrument variability M. Link et al. 10.5194/amt-18-1013-2025
- Recent advances in mass spectrometry techniques for atmospheric chemistry research on molecular‐level W. Zhang et al. 10.1002/mas.21857
- Photodegradation of naphthalene-derived particle oxidation products F. Sari Doré et al. 10.1039/D4EA00125G
- Quantitative Determination of Volatile N-Nitrosamines in Meat Products Using Gas Chromatography Coupled to an Ion Mobility Spectrometer with an Ammonia Dopant C. Wang et al. 10.1021/acs.jafc.4c07826
- Optimizing the iodide-adduct chemical ionization mass spectrometry (CIMS) quantitative method for toluene oxidation intermediates: experimental insights into functional-group differences M. Song et al. 10.5194/amt-17-5113-2024
- Online Calibration of a Chemical Ionization Mass Spectrometer for Multifunctional Biogenic Organic Nitrates M. Robinson et al. 10.1021/acsestair.4c00056
- Analysis of Fentanyl and Fentanyl Analogs Using Atmospheric Pressure Chemical Ionization Gas Chromatography–Mass Spectrometry (APCI-GC-MS) K. Reyes Monroy et al. 10.1021/jasms.4c00455
- Extending the Range of Detectable Trace Species with the Fast Polarity Switching of Chemical Ionization Orbitrap Mass Spectrometry R. Cai et al. 10.1021/acs.analchem.4c00650
- Effects of Relative Humidity on Time-Resolved Molecular Characterization of Secondary Organic Aerosols from the OH-Initiated Oxidation of Cresol in the Presence of NOx C. Carstens et al. 10.1021/acs.est.4c08215
- Constraining Gas Phase Yields and Reactive Uptake Coefficients of Oxidation Products from the Hydroxyl Radical-Isoprene Reaction onto Acidic Particles by Vocus Ammonia-Adduct Chemical Ionization Mass Spectrometry (Vocus NH4+ CIMS) J. Zhao et al. 10.1021/acsestair.4c00367
- Measuring pesticides in the atmosphere: current status, emerging trends and future perspectives M. Brüggemann et al. 10.1186/s12302-024-00870-4
- Rapid screening of volatile chemicals in surface water samples from the East Palestine, Ohio chemical disaster site with proton transfer reaction mass spectrometry J. Jiang et al. 10.1016/j.scitotenv.2024.176056
Latest update: 30 May 2025
Short summary
We describe the development and operation of a chemical ionization mass spectrometer using an ammonium–water cluster (NH4+·H2O) as a reagent ion. NH4+·H2O is a highly versatile reagent ion for measurements of a wide range of oxygenated organic compounds. The major product ion is the cluster with NH4+ produced via ligand-switching reactions. The instrumental sensitivities of analytes depend on the binding energy of the analyte–NH4+ cluster; sensitivities can be estimated using voltage scanning.
We describe the development and operation of a chemical ionization mass spectrometer using an...
