Uncrewed aerial vehicles (UAVs) equipped with greenhouse gas (GHG) analyzers are crucial for monitoring hard-to-reach areas where traditional techniques are impractical. Here, we deployed UAVs with different types of GHG analyzers and applied three different emission rate quantification methods over a known geological methane seep. Our results demonstrate that UAV-based approaches can reliably quantify emissions from remote methane point sources that would otherwise be difficult to measure.