Articles | Volume 14, issue 12
https://doi.org/10.5194/amt-14-7579-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/amt-14-7579-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Research article
| 
07 Dec 2021
Research article |
| 07 Dec 2021
| 07 Dec 2021
A semi-automated instrument for cellular oxidative potential evaluation (SCOPE) of water-soluble extracts of ambient particulate matter
Sudheer Salana
Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, 61801, USA
Yixiang Wang
Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, 61801, USA
Joseph V. Puthussery
Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, 61801, USA
Vishal Verma
CORRESPONDING AUTHOR
Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, 61801, USA
Related authors
No articles found.
Pamela A. Dominutti, Jean-Luc Jaffrezo, Anouk Marsal, Takoua Mhadhbi, Rhabira Elazzouzi, Camille Rak, Fabrizia Cavalli, Jean-Philippe Putaud, Aikaterini Bougiatioti, Nikolaos Mihalopoulos, Despina Paraskevopoulou, Ian S. Mudway, Athanasios Nenes, Kaspar R. Daellenbach, Catherine Banach, Steven J. Campbell, Hana Cigánková, Daniele Contini, Greg Evans, Maria Georgopoulou, Manuella Ghanem, Drew A. Glencross, Maria Rachele Guascito, Hartmut Herrmann, Saima Iram, Maja Jovanović, Milena Jovašević-Stojanović, Markus Kalberer, Ingeborg M. Kooter, Suzanne E. Paulson, Anil Patel, Esperanza Perdrix, Maria Chiara Pietrogrande, Pavel Mikuška, Jean-Jacques Sauvain, Aikaterina Seitanidi, Pourya Shahpoury, Eduardo J. S. Souza, Sarah Steimer, Svetlana Stevanovic, Guillaume Suarez, P. S. Ganesh Subramanian, Battist Utinger, Marloes F. van Os, Vishal Verma, Xing Wang, Rodney J. Weber, Yuhan Yang, Xavier Querol, Gerard Hoek, Roy M. Harrison, and Gaëlle Uzu
Atmos. Meas. Tech. Discuss., https://doi.org/10.5194/amt-2024-107, https://doi.org/10.5194/amt-2024-107, 2024
Revised manuscript accepted for AMT
Short summary
Short summary
In this work, 20 labs worldwide collaborated to evaluate the measurement of air pollution's oxidative potential (OP), a key indicator of its harmful effects. The study aimed to identify disparities in the widely used OP DTT assay and assess the consistency of OP among labs using the same protocol. The results showed that half of the labs achieved acceptable results. However, variability was also found, highlighting the need for standardization in OP procedures.
Varun Kumar, Stamatios Giannoukos, Sophie L. Haslett, Yandong Tong, Atinderpal Singh, Amelie Bertrand, Chuan Ping Lee, Dongyu S. Wang, Deepika Bhattu, Giulia Stefenelli, Jay S. Dave, Joseph V. Puthussery, Lu Qi, Pawan Vats, Pragati Rai, Roberto Casotto, Rangu Satish, Suneeti Mishra, Veronika Pospisilova, Claudia Mohr, David M. Bell, Dilip Ganguly, Vishal Verma, Neeraj Rastogi, Urs Baltensperger, Sachchida N. Tripathi, André S. H. Prévôt, and Jay G. Slowik
Atmos. Chem. Phys., 22, 7739–7761, https://doi.org/10.5194/acp-22-7739-2022, https://doi.org/10.5194/acp-22-7739-2022, 2022
Short summary
Short summary
Here we present source apportionment results from the first field deployment in Delhi of an extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF). The EESI-TOF is a recently developed instrument capable of providing uniquely detailed online chemical characterization of organic aerosol (OA), in particular the secondary OA (SOA) fraction. Here, we are able to apportion not only primary OA but also SOA to specific sources, which is performed for the first time in Delhi.
Haoran Yu, Joseph Varghese Puthussery, Yixiang Wang, and Vishal Verma
Atmos. Chem. Phys., 21, 16363–16386, https://doi.org/10.5194/acp-21-16363-2021, https://doi.org/10.5194/acp-21-16363-2021, 2021
Short summary
Short summary
We assessed the oxidative potential (OP) of ambient PM2.5 collected from many sites in the US Midwest through multiple acellular endpoints. Compared to homogeneously distributed PM2.5, OP showed higher spatiotemporal variation. Poor correlations for the regression between mass and OP indicated a limited role of mass in determining the OP. Moreover, weak correlations among different OP endpoints justify the need for using multiple assays to determine oxidative levels of particles.
Joseph V. Puthussery, Chen Zhang, and Vishal Verma
Atmos. Meas. Tech., 11, 5767–5780, https://doi.org/10.5194/amt-11-5767-2018, https://doi.org/10.5194/amt-11-5767-2018, 2018
Short summary
Short summary
The oxidative potential (OP) of ambient particulate matter (PM) has recently gained attention as an alternative metric for assessing the ambient PM toxicity. However, a major constraint in measuring the OP is its labor-intensive protocol. Here, we developed a new online instrument by coupling a mist chamber to an automated analytical system which can measure the real-time OP of ambient PM. We also report for the first time, the hourly averaged diurnal profile of ambient PM OP at an urban site.
Dong Gao, Ting Fang, Vishal Verma, Linghan Zeng, and Rodney J. Weber
Atmos. Meas. Tech., 10, 2821–2835, https://doi.org/10.5194/amt-10-2821-2017, https://doi.org/10.5194/amt-10-2821-2017, 2017
Short summary
Short summary
This work compares three methods to determine the optimal approach for quantifying the total oxidative potential (OP) of fine particles collected with filters using the dithiothreitol (DTT) assay. An automated system has been developed to facilitate the total OP measurements for use in generation of large data sets needed for epidemiology studies. The results from this study show that the water-insoluble components contribute to PM2.5 OP and the related DTT-active species are largely secondary.
Ting Fang, Vishal Verma, Josephine T. Bates, Joseph Abrams, Mitchel Klein, Matthew J. Strickland, Stefanie E. Sarnat, Howard H. Chang, James A. Mulholland, Paige E. Tolbert, Armistead G. Russell, and Rodney J. Weber
Atmos. Chem. Phys., 16, 3865–3879, https://doi.org/10.5194/acp-16-3865-2016, https://doi.org/10.5194/acp-16-3865-2016, 2016
Short summary
Short summary
Ascorbic acid (AA) and Dithiothreitol (DTT) assay measures of water-soluble PM2.5 oxidative potential (OP) are compared in terms of spatiotemporal trends, chemical selectivity, sources, and health impacts based on an epidemiological study with backcast estimated OP. Both assays point to metals from brake/tire wear, but only the DTT assay also identifies organics from combustion. DTT is associated with emergency department visits for asthma/wheeze and congestive heart failure, whereas AA is not.
T. Fang, H. Guo, V. Verma, R. E. Peltier, and R. J. Weber
Atmos. Chem. Phys., 15, 11667–11682, https://doi.org/10.5194/acp-15-11667-2015, https://doi.org/10.5194/acp-15-11667-2015, 2015
Short summary
Short summary
This work presented a new method of quantifying water-soluble elements in PM2.5 aqueous extracts (N~500) with an X-ray fluorescence analyzer. The results indicate that water-soluble elements had marked spatial and temporal patterns. Four sources were resolved: brake/tire wear, biomass burning, secondary formation, and mineral dust. The findings have informed studies on aerosol oxidative potential and provided insights into the health effects of water-soluble metals, especially Cu, Fe, Mn and Zn.
T. Fang, V. Verma, H. Guo, L. E. King, E. S. Edgerton, and R. J. Weber
Atmos. Meas. Tech., 8, 471–482, https://doi.org/10.5194/amt-8-471-2015, https://doi.org/10.5194/amt-8-471-2015, 2015
Short summary
Short summary
This work summarizes a newly developed semi-automated system for quantifying the oxidative potential of aerosol aqueous extracts using the dithiothreitol (DTT) assay. 500 sample analyses indicate that DTT activity in the southeast US is likely not dominated by a unique local source, and sources change with season. The unique large data set generated with the technique described in this paper allows new studies on DTT sources and investigating linkages between reactive oxygen species and health.
V. Verma, T. Fang, H. Guo, L. King, J. T. Bates, R. E. Peltier, E. Edgerton, A. G. Russell, and R. J. Weber
Atmos. Chem. Phys., 14, 12915–12930, https://doi.org/10.5194/acp-14-12915-2014, https://doi.org/10.5194/acp-14-12915-2014, 2014
Short summary
Short summary
The major emission sources of the reactive oxygen species (ROS) associated with ambient particulate matter in the southeastern United States were identified. The study shows biomass burning and secondary aerosol formation as the major sources contributing to the ROS-generating capability of ambient particles. The ubiquitous nature of these two sources suggests widespread population exposures to the toxic aerosol components.
S. H. Budisulistiorini, M. R. Canagaratna, P. L. Croteau, K. Baumann, E. S. Edgerton, M. S. Kollman, N. L. Ng, V. Verma, S. L. Shaw, E. M. Knipping, D. R. Worsnop, J. T. Jayne, R.J. Weber, and J. D. Surratt
Atmos. Meas. Tech., 7, 1929–1941, https://doi.org/10.5194/amt-7-1929-2014, https://doi.org/10.5194/amt-7-1929-2014, 2014
Related subject area
Subject: Aerosols | Technique: Laboratory Measurement | Topic: Instruments and Platforms
Rapid quantitative analysis of semi-volatile organic compounds in indoor surface film using direct analysis in real time mass spectrometry: a case study on phthalates
Exploring non-soluble particles in hailstones through innovative confocal laser and scanning electron microscopy techniques
A comprehensive evaluation of enhanced temperature influence on gas and aerosol chemistry in the lamp-enclosed oxidation flow reactor (OFR) system
A Novel Methodology for Assessing the Hygroscopicity of Aerosol Filter Samples
An oxidation flow reactor for simulating and accelerating secondary aerosol formation in aerosol liquid water and cloud droplets
Surface equilibrium vapor pressure of organic nanoparticles measured from the dynamic-aerosol-size electrical mobility spectrometer
Quality assurance and quality control of atmospheric organosulfates measured using hydrophilic interaction liquid chromatography (HILIC)
Micro-PINGUIN: microtiter-plate-based instrument for ice nucleation detection in gallium with an infrared camera
Characterization of the Vaporization Inlet for Aerosols (VIA) for online measurements of particulate highly oxygenated organic molecules (HOMs)
Development and characterization of a high-performance single-particle aerosol mass spectrometer (HP-SPAMS)
Merging holography, fluorescence, and machine learning for in situ, continuous characterization and classification of airborne microplastics
Characterization of the planar differential mobility analyzer (DMA P5): resolving power, transmission efficiency and its application to atmospheric relevant cluster measurements
Airborne bacteria viability and air quality: a protocol to quantitatively investigate the possible correlation by an atmospheric simulation chamber
The viscosity and surface tension of supercooled levitated droplets determined by excitation of shape oscillations
Acoustic levitation of pollen and visualisation of hygroscopic behaviour
Concept, absolute calibration, and validation of a new benchtop laser imaging polar nephelometer
A new smog chamber system for atmospheric multiphase chemistry study: design and characterization
Stability assessment of organic sulfur and organosulfate compounds in filter samples for quantification by Fourier- transform infrared spectroscopy
Design and evaluation of a thermal precipitation aerosol electrometer (TPAE)
An automated online field instrument to quantify the oxidative potential of aerosol particles via ascorbic acid oxidation
Online measurement of highly oxygenated compounds from organic aerosol
The AERosol and TRACe gas Collector (AERTRACC): an online-measurement-controlled sampler for source-resolved emission analysis
Quantitative chemical assay of nanogram-level particulate matter using aerosol mass spectrometry: characterization of particles collected from uncrewed atmospheric measurement platforms
An optimised organic carbon ∕ elemental carbon (OC ∕ EC) fraction separation method for radiocarbon source apportionment applied to low-loaded Arctic aerosol filters
Investigating the dependence of mineral dust depolarization on complex refractive index and size with a laboratory polarimeter at 180.0° lidar backscattering angle
Evaluation of a low-cost dryer for a low-cost optical particle counter
Effects of temperature and salinity on bubble-bursting aerosol formation simulated with a bubble-generating chamber
A new hot-stage microscopy technique for measuring temperature-dependent viscosities of aerosol particles and its application to farnesene secondary organic aerosol
Characterization of a modified printed optical particle spectrometer for high-frequency and high-precision laboratory and field measurements
Design and fabrication of an electrostatic precipitator for infrared spectroscopy
Combined application of online FIGAERO-CIMS and offline LC-Orbitrap mass spectrometry (MS) to characterize the chemical composition of secondary organic aerosol (SOA) in smog chamber studies
High-frequency gaseous and particulate chemical characterization using extractive electrospray ionization mass spectrometry (Dual-Phase-EESI-TOF)
An evaluation of the heat test for the ice-nucleating ability of minerals and biological material
Development, characterization, and application of an improved online reactive oxygen species analyzer based on the Monitor for AeRosols and Gases in ambient Air (MARGA)
Characterization of soot produced by the mini inverted soot generator with an atmospheric simulation chamber
LED-based solar simulator to study photochemistry over a wide temperature range in the large simulation chamber AIDA
Laboratory evaluation of the scattering matrix of ragweed, ash, birch and pine pollen towards pollen classification
Cloud condensation nuclei (CCN) activity analysis of low-hygroscopicity aerosols using the aerodynamic aerosol classifier (AAC)
Characterisation of the Manchester Aerosol Chamber facility
A study on the fragmentation of sulfuric acid and dimethylamine clusters inside an atmospheric pressure interface time-of-flight mass spectrometer
Utilizing an electrical low-pressure impactor to indirectly probe water uptake via particle bounce measurements
Calibration and evaluation of a broad supersaturation scanning (BS2) cloud condensation nuclei counter for rapid measurement of particle hygroscopicity and cloud condensation nuclei (CCN) activity
Correcting bias in log-linear instrument calibrations in the context of chemical ionization mass spectrometry
Effects of aerosol size and coating thickness on the molecular detection using extractive electrospray ionization
The nano-scanning electrical mobility spectrometer (nSEMS) and its application to size distribution measurements of 1.5–25 nm particles
A dual-droplet approach for measuring the hygroscopicity of aqueous aerosol
A method for liquid spectrophotometric measurement of total and water-soluble iron and copper in ambient aerosols
Efficacy of a portable, moderate-resolution, fast-scanning differential mobility analyzer for ambient aerosol size distribution measurements
Comparative characterization of the performance of bio-aerosol nebulizers in connection with atmospheric simulation chambers
Coupling a gas chromatograph simultaneously to a flame ionization detector and chemical ionization mass spectrometer for isomer-resolved measurements of particle-phase organic compounds
Ying Zhou, Longkun He, Jiang Tan, Jiang Zhou, and Yingjun Liu
Atmos. Meas. Tech., 17, 6415–6423, https://doi.org/10.5194/amt-17-6415-2024, https://doi.org/10.5194/amt-17-6415-2024, 2024
Short summary
Short summary
We present a sensitive DART-MS/MS method for the fast and accurate quantification of semi-volatile organic compounds (SVOCs) in organic films without the need for pre-treatment. This method offers greatly improved repeatability in the absence of internal standards. By utilizing MS/MS analysis, the separation of isomeric components within films becomes possible. These developments increase the feasibility of the DART-MS approach for studying the dynamics of SVOCs in indoor surface films.
Anthony C. Bernal Ayala, Angela K. Rowe, Lucia E. Arena, William O. Nachlas, and Maria L. Asar
Atmos. Meas. Tech., 17, 5561–5579, https://doi.org/10.5194/amt-17-5561-2024, https://doi.org/10.5194/amt-17-5561-2024, 2024
Short summary
Short summary
Hail is a challenging weather phenomenon to forecast due to an incomplete understanding of hailstone formation. Microscopy temperature limitations required previous studies to melt hail for analysis. This paper introduces a unique technique using a plastic cover to preserve particles in their location within the hailstone without melting. Therefore, CLSM and SEM–EDS microscopes can be used to determine individual particle sizes and their chemical composition related to hail-formation processes.
Tianle Pan, Andrew T. Lambe, Weiwei Hu, Yicong He, Minghao Hu, Huaishan Zhou, Xinming Wang, Qingqing Hu, Hui Chen, Yue Zhao, Yuanlong Huang, Doug R. Worsnop, Zhe Peng, Melissa A. Morris, Douglas A. Day, Pedro Campuzano-Jost, Jose-Luis Jimenez, and Shantanu H. Jathar
Atmos. Meas. Tech., 17, 4915–4939, https://doi.org/10.5194/amt-17-4915-2024, https://doi.org/10.5194/amt-17-4915-2024, 2024
Short summary
Short summary
This study systematically characterizes the temperature enhancement in the lamp-enclosed oxidation flow reactor (OFR). The enhancement varied multiple dimensional factors, emphasizing the complexity of temperature inside of OFR. The effects of temperature on the flow field and gas- or particle-phase reaction inside OFR were also evaluated with experiments and model simulations. Finally, multiple mitigation strategies were demonstrated to minimize this temperature increase.
Nagendra Raparthi, Anthony S. Wexler, and Ann M. Dillner
EGUsphere, https://doi.org/10.5194/egusphere-2024-2482, https://doi.org/10.5194/egusphere-2024-2482, 2024
Short summary
Short summary
Quantifying the composition-dependent hygroscopicity of aerosol particles is essential for advancing our understanding of atmospheric processes. Existing methods do not integrate chemical composition with hygroscopicity. We developed a novel method to assess the water uptake of particles sampled on aerosol filters at relative humidity levels up to 97 % and link it with their composition. This approach allows for the separation of total water uptake into inorganic and organic components.
Ningjin Xu, Chen Le, David R. Cocker, Kunpeng Chen, Ying-Hsuan Lin, and Don R. Collins
Atmos. Meas. Tech., 17, 4227–4243, https://doi.org/10.5194/amt-17-4227-2024, https://doi.org/10.5194/amt-17-4227-2024, 2024
Short summary
Short summary
A flow-through reactor was developed that exposes known mixtures of gases or ambient air to very high concentrations of the oxidants that are responsible for much of the chemistry that takes place in the atmosphere. Like other reactors of its type, it is primarily used to study the formation of particulate matter from the oxidation of common gases. Unlike other reactors of its type, it can simulate the chemical reactions that occur in liquid water that is present in particles or cloud droplets.
Ella Häkkinen, Huan Yang, Runlong Cai, and Juha Kangasluoma
Atmos. Meas. Tech., 17, 4211–4225, https://doi.org/10.5194/amt-17-4211-2024, https://doi.org/10.5194/amt-17-4211-2024, 2024
Short summary
Short summary
We report measurements of evaporation kinetics and surface equilibrium vapor pressures for various laboratory-generated organic nanoparticles using the dynamic-aerosol-size electrical mobility spectrometer (DEMS), a recent advancement in aerosol process characterization. Our findings align well with literature values, demonstrating DEMS's effectiveness. We suggest future improvements to DEMS and anticipate its potential for probing aerosol-related kinetic processes with unknown mechanisms.
Ping Liu, Xiang Ding, Bo-Xuan Li, Yu-Qing Zhang, Daniel J. Bryant, and Xin-Ming Wang
Atmos. Meas. Tech., 17, 3067–3079, https://doi.org/10.5194/amt-17-3067-2024, https://doi.org/10.5194/amt-17-3067-2024, 2024
Short summary
Short summary
In this paper, we further optimize the measurement of atmospheric organosulfates by hydrophilic interaction liquid chromatography (HILIC), offering an improved method for quantifying and speciating atmospheric organosulfates. These efforts will contribute to a deeper understanding of secondary organic aerosol precursors, formation mechanisms, and the contribution of organosulfate to atmospheric aerosols, ultimately guiding research in the field of air pollution prevention and control.
Corina Wieber, Mads Rosenhøj Jeppesen, Kai Finster, Claus Melvad, and Tina Šantl-Temkiv
Atmos. Meas. Tech., 17, 2707–2719, https://doi.org/10.5194/amt-17-2707-2024, https://doi.org/10.5194/amt-17-2707-2024, 2024
Short summary
Short summary
We developed a novel instrument to determine the quality and number of biological and non-biological particles, with respect to their ice-promoting capacity as a function of temperature. The measurement uncertainty was determined, and the instrument produced reliable results. Further, repeated measurements of the same suspension showed that the instrument had high reproducibility.
Jian Zhao, Valter Mickwitz, Yuanyuan Luo, Ella Häkkinen, Frans Graeffe, Jiangyi Zhang, Hilkka Timonen, Manjula Canagaratna, Jordan E. Krechmer, Qi Zhang, Markku Kulmala, Juha Kangasluoma, Douglas Worsnop, and Mikael Ehn
Atmos. Meas. Tech., 17, 1527–1543, https://doi.org/10.5194/amt-17-1527-2024, https://doi.org/10.5194/amt-17-1527-2024, 2024
Short summary
Short summary
Organic aerosol constitutes a significant portion of atmospheric fine particles but is less characterized due to its vast number of constituents. Recently, we developed a system for online measurements of particle-phase highly oxygenated organic molecules (HOMs). In this work, we systematically characterized the system, developed a new unit to enhance its performance, and demonstrated the essential role of thermograms in inferring volatility and quantifying HOMs in organic aerosols.
Xubing Du, Qinhui Xie, Qing Huang, Xuan Li, Junlin Yang, Zhihui Hou, Jingjing Wang, Xue Li, Zhen Zhou, Zhengxu Huang, Wei Gao, and Lei Li
Atmos. Meas. Tech., 17, 1037–1050, https://doi.org/10.5194/amt-17-1037-2024, https://doi.org/10.5194/amt-17-1037-2024, 2024
Short summary
Short summary
Currently, the limitations of single-particle mass spectrometry detection capabilities render it not yet well suited for analyzing complex aerosol components in low-concentration environments. In this study, a new high-performance single-particle aerosol mass spectrometer (HP-SPAMS) is developed to enhance instrument performance regarding the number of detected particles, transmission efficiency, resolution, and sensitivity, which will help in aerosol science.
Nicholas D. Beres, Julia Burkart, Elias Graf, Yanick Zeder, Lea Ann Dailey, and Bernadett Weinzierl
EGUsphere, https://doi.org/10.5194/egusphere-2023-2853, https://doi.org/10.5194/egusphere-2023-2853, 2023
Short summary
Short summary
We tested a new method to identify airborne microplastics (MPs), merging imaging, fluorescence, and machine learning of single particles. We examined whether combining imaging and fluorescence data enhances classification accuracy compared to using each method separately and tested these methods with other particle types. The tested MPs have distinct fluorescence and a combined imaging + fluorescence method improves their detection, making meaningful progress in monitoring MPs in the atmosphere.
Zhengning Xu, Jian Gao, Zhuanghao Xu, Michel Attoui, Xiangyu Pei, Mario Amo-González, Kewei Zhang, and Zhibin Wang
Atmos. Meas. Tech., 16, 5995–6006, https://doi.org/10.5194/amt-16-5995-2023, https://doi.org/10.5194/amt-16-5995-2023, 2023
Short summary
Short summary
Planar differential mobility analyzers (DMAs) have higher ion transmission efficiency and sizing resolution compared to cylindrical DMAs and are more suitable for use with mass spectrometers (MSs). Performance of the latest planar DMA (P5) was characterized. Sizing resolution and ion transmission efficiency were 5–16 times and ∼10 times higher than cylindrical DMAs. Sulfuric acid clusters were measured by DMA(P5)-MSs. This technique can be applied for natural products and biomolecule analysis.
Virginia Vernocchi, Elena Abd El, Marco Brunoldi, Silvia Giulia Danelli, Elena Gatta, Tommaso Isolabella, Federico Mazzei, Franco Parodi, Paolo Prati, and Dario Massabò
Atmos. Meas. Tech., 16, 5479–5493, https://doi.org/10.5194/amt-16-5479-2023, https://doi.org/10.5194/amt-16-5479-2023, 2023
Short summary
Short summary
Bioaerosol are airborne particles or droplets that contain living organisms or biological materials, such as bacteria, viruses, fungi, pollen, or other organic matter. The study of the relationship between bioaerosol viability and air quality or meteorological conditions is an open field, and running experiments of the bioareosol viability in an atmospheric simulation chamber gives the possibility to set up well-defined conditions to evaluate the interaction between bioaerosol and pollutants.
Mohit Singh, Stephanie Helen Jones, Alexei Kiselev, Denis Duft, and Thomas Leisner
Atmos. Meas. Tech., 16, 5205–5215, https://doi.org/10.5194/amt-16-5205-2023, https://doi.org/10.5194/amt-16-5205-2023, 2023
Short summary
Short summary
We introduce a novel method for simultaneous measurement of the viscosity and surface tension of metastable liquids. Our approach is based on the phase analysis of excited shape oscillations in levitated droplets. It is applicable to a wide range of atmospheric conditions and can monitor changes in real time. The technique holds great promise for investigating the effect of atmospheric processing on the viscosity and surface tension of solution droplets in equilibrium with water vapour.
Sophie A. Mills, Adam Milsom, Christian Pfrang, A. Rob MacKenzie, and Francis D. Pope
Atmos. Meas. Tech., 16, 4885–4898, https://doi.org/10.5194/amt-16-4885-2023, https://doi.org/10.5194/amt-16-4885-2023, 2023
Short summary
Short summary
Pollen grains are important components of the atmosphere and have the potential to impact upon cloud processes via their ability to help in the formation of rain droplets. This study investigates the hygroscopicity of two different pollen species using an acoustic levitator. Pollen grains are levitated, and their response to changes in relative humidity is investigated. A key advantage of this method is that it is possible study pollen shape under varying environmental conditions.
Alireza Moallemi, Robin L. Modini, Benjamin T. Brem, Barbara Bertozzi, Philippe Giaccari, and Martin Gysel-Beer
Atmos. Meas. Tech., 16, 3653–3678, https://doi.org/10.5194/amt-16-3653-2023, https://doi.org/10.5194/amt-16-3653-2023, 2023
Short summary
Short summary
Polarimetric data, i.e., the angular and polarization dependence of light scattering by aerosols, contain ample information on optical and microphysical properties. Retrieval of these properties is a central approach in aerosol remote sensing. We present a description, calibration, validation, and a first application of a new benchtop polar nephelometer, which provides in situ polarimetric measurements of an aerosol. Such data facilitate agreement between retrieval results and independent data.
Taomou Zong, Zhijun Wu, Junrui Wang, Kai Bi, Wenxu Fang, Yanrong Yang, Xuena Yu, Zhier Bao, Xiangxinyue Meng, Yuheng Zhang, Song Guo, Yang Chen, Chunshan Liu, Yue Zhang, Shao-Meng Li, and Min Hu
Atmos. Meas. Tech., 16, 3679–3692, https://doi.org/10.5194/amt-16-3679-2023, https://doi.org/10.5194/amt-16-3679-2023, 2023
Short summary
Short summary
This study developed and characterized an indoor chamber system (AIR) to simulate atmospheric multiphase chemistry processes. The AIR chamber can accurately control temperature and relative humidity (RH) over a broad range and simulate diurnal variation of ambient atmospheric RH. The aerosol generation unit can generate organic-coating seed particles with different phase states. The AIR chamber demonstrates high-quality performance in simulating secondary aerosol formation.
Marife B. Anunciado, Miranda De Boskey, Laura Haines, Katarina Lindskog, Tracy Dombek, Satoshi Takahama, and Ann M. Dillner
Atmos. Meas. Tech., 16, 3515–3529, https://doi.org/10.5194/amt-16-3515-2023, https://doi.org/10.5194/amt-16-3515-2023, 2023
Short summary
Short summary
Organic sulfur compounds are used to identify sources and atmospheric processing of aerosol. Our paper evaluates the potential of using a non-destructive measurement technique to measure organic sulfur compounds in filter samples by assessing their chemical stability over time. Some were stable, but some evaporated or changed chemically. Future work includes evaluating the stability and potential interference of multiple organic sulfur compounds in laboratory mixtures and ambient aerosol.
Shipeng Kang, Tongzhu Yu, Yixin Yang, Jiguang Wang, Huaqiao Gui, Jianguo Liu, and Da-Ren Chen
Atmos. Meas. Tech., 16, 3245–3255, https://doi.org/10.5194/amt-16-3245-2023, https://doi.org/10.5194/amt-16-3245-2023, 2023
Short summary
Short summary
A new aerosol electrometer, the thermal precipitation aerosol electrometer (TPAE), was designed for particles in sizes less than 300 nm, and its prototype performance was experimentally evaluated. The TPAE combines the thermal precipitator in the disk-to-disk configuration with a microcurrent measurement circuit board (i.e., pre-amplifier) for measuring the current carried by collected particles. Our performance study shows that the TPAE performance is consistent with the reference.
Battist Utinger, Steven John Campbell, Nicolas Bukowiecki, Alexandre Barth, Benjamin Gfeller, Ray Freshwater, Hans-Rudolf Rüegg, and Markus Kalberer
Atmos. Meas. Tech., 16, 2641–2654, https://doi.org/10.5194/amt-16-2641-2023, https://doi.org/10.5194/amt-16-2641-2023, 2023
Short summary
Short summary
Exposure to atmospheric aerosols can lead to adverse health effect, but particle components responsible for this are unknown. Redox-active compounds, some with very short lifetimes, are considered to be a toxic class of compounds in particles. We developed the first online field instrument to quantify short-lived and stable redox-active compounds with a physiological assay based on ascorbic acid and a high time resolution and detection limits to allow measurements at unpolluted locations.
Ella Häkkinen, Jian Zhao, Frans Graeffe, Nicolas Fauré, Jordan E. Krechmer, Douglas Worsnop, Hilkka Timonen, Mikael Ehn, and Juha Kangasluoma
Atmos. Meas. Tech., 16, 1705–1721, https://doi.org/10.5194/amt-16-1705-2023, https://doi.org/10.5194/amt-16-1705-2023, 2023
Short summary
Short summary
Highly oxygenated compounds contribute to the formation and growth of atmospheric organic aerosol and thus impact the global climate. Knowledge of their transformations and fate after condensing into the particle phase has been limited by the lack of suitable detection techniques. Here, we present an online method for measuring highly oxygenated compounds from organic aerosol. We evaluate the performance of the method and demonstrate that the method is applicable to different organic species.
Julia Pikmann, Lasse Moormann, Frank Drewnick, and Stephan Borrmann
Atmos. Meas. Tech., 16, 1323–1341, https://doi.org/10.5194/amt-16-1323-2023, https://doi.org/10.5194/amt-16-1323-2023, 2023
Short summary
Short summary
Aerosols measured in complex environments are usually a mixture of emissions from different sources. To characterize sources individually, we developed a sampling system for particles and organic trace gases which is coupled to real-time data of physical and chemical aerosol properties, gas concentrations, and meteorological variables. Using suitable sampling conditions for individual aerosols which are compared with the real-time data the desired aerosols are sampled separately from each other.
Christopher R. Niedek, Fan Mei, Maria A. Zawadowicz, Zihua Zhu, Beat Schmid, and Qi Zhang
Atmos. Meas. Tech., 16, 955–968, https://doi.org/10.5194/amt-16-955-2023, https://doi.org/10.5194/amt-16-955-2023, 2023
Short summary
Short summary
This novel micronebulization aerosol mass spectrometry (MS) technique requires a low sample volume (10 μL) and can quantify nanogram levels of organic and inorganic particulate matter (PM) components when used with 34SO4. This technique was successfully applied to PM samples collected from uncrewed atmospheric measurement platforms and provided chemical information that agrees well with real-time data from a co-located aerosol chemical speciation monitor and offline data from secondary ion MS.
Martin Rauber, Gary Salazar, Karl Espen Yttri, and Sönke Szidat
Atmos. Meas. Tech., 16, 825–844, https://doi.org/10.5194/amt-16-825-2023, https://doi.org/10.5194/amt-16-825-2023, 2023
Short summary
Short summary
Carbon-containing aerosols from ambient air are analysed for radioactive isotope radiocarbon to determine the contribution from fossil-fuel emissions. Light-absorbing soot-like aerosols are isolated by water extraction and thermal separation. This separation is affected by artefacts, for which we developed a new correction method. The investigation of aerosols from the Arctic shows that our approach works well for such samples, where many artefacts are expected.
Alain Miffre, Danaël Cholleton, Clément Noël, and Patrick Rairoux
Atmos. Meas. Tech., 16, 403–417, https://doi.org/10.5194/amt-16-403-2023, https://doi.org/10.5194/amt-16-403-2023, 2023
Short summary
Short summary
The depolarization ratio of hematite, silica, Arizona and Asian dust is evaluated in a lab with a π-polarimeter operating at lidar 180 ° and at (355, 532) nm wavelengths. The hematite depolarization equals (10±1) % at 355 nm for coarser particles, while that of silica is (33±1) %. This huge difference is explained by accounting for the high imaginary part of the hematite complex refractive index, thus revealing the key role played by light absorption in mineral dust lidar depolarization.
Miriam Chacón-Mateos, Bernd Laquai, Ulrich Vogt, and Cosima Stubenrauch
Atmos. Meas. Tech., 15, 7395–7410, https://doi.org/10.5194/amt-15-7395-2022, https://doi.org/10.5194/amt-15-7395-2022, 2022
Short summary
Short summary
The study evaluates a low-cost dryer to avoid the negative effect of hygroscopic growth and fog droplets in the particulate matter (PM) concentrations of sensors. The results show a reduction in the overestimation of the PM but also an underestimation compared to reference devices. Special care is needed when designing a dryer as high temperatures change the sampled air by evaporating the most volatile particulate species. Low-cost dryers are very promising for different sensor applications.
Svetlana Sofieva, Eija Asmi, Nina S. Atanasova, Aino E. Heikkinen, Emeline Vidal, Jonathan Duplissy, Martin Romantschuk, Rostislav Kouznetsov, Jaakko Kukkonen, Dennis H. Bamford, Antti-Pekka Hyvärinen, and Mikhail Sofiev
Atmos. Meas. Tech., 15, 6201–6219, https://doi.org/10.5194/amt-15-6201-2022, https://doi.org/10.5194/amt-15-6201-2022, 2022
Short summary
Short summary
A new bubble-generating glass chamber design with an extensive set of aerosol production experiments is presented to re-evaluate bubble-bursting-mediated aerosol production as a function of water parameters: bubbling air flow, water salinity, and temperature. Our main findings suggest modest dependence of aerosol production on the water salinity and a strong dependence on temperature below ~ 10 °C.
Kristian J. Kiland, Kevin L. Marroquin, Natalie R. Smith, Shaun Xu, Sergey A. Nizkorodov, and Allan K. Bertram
Atmos. Meas. Tech., 15, 5545–5561, https://doi.org/10.5194/amt-15-5545-2022, https://doi.org/10.5194/amt-15-5545-2022, 2022
Short summary
Short summary
Information on the viscosity of secondary organic aerosols is needed when making air quality, climate, and atmospheric chemistry predictions. Viscosity depends on temperature, so we developed a new method for measuring the temperature-dependent viscosity of small samples. As an application of the method, we measured the viscosity of farnesene secondary organic aerosol at different temperatures.
Sabin Kasparoglu, Mohammad Maksimul Islam, Nicholas Meskhidze, and Markus D. Petters
Atmos. Meas. Tech., 15, 5007–5018, https://doi.org/10.5194/amt-15-5007-2022, https://doi.org/10.5194/amt-15-5007-2022, 2022
Short summary
Short summary
A modified version of a Handix Scientific printed optical particle spectrometer is introduced. The paper presents characterization experiments, including concentration, size, and time responses. Integration of an external multichannel analyzer card removes counting limitations of the original instrument. It is shown that the high-resolution light-scattering amplitude data can be used to sense particle-phase transitions.
Nikunj Dudani and Satoshi Takahama
Atmos. Meas. Tech., 15, 4693–4707, https://doi.org/10.5194/amt-15-4693-2022, https://doi.org/10.5194/amt-15-4693-2022, 2022
Short summary
Short summary
We designed and fabricated an aerosol collector with high collection efficiency that enables quantitative infrared spectroscopy analysis. By collecting particles on optical windows, typical substrate interferences are eliminated. New methods for fabricating aerosol devices using 3D printing with post-treatment to reduce the time and cost of prototyping are described.
Mao Du, Aristeidis Voliotis, Yunqi Shao, Yu Wang, Thomas J. Bannan, Kelly L. Pereira, Jacqueline F. Hamilton, Carl J. Percival, M. Rami Alfarra, and Gordon McFiggans
Atmos. Meas. Tech., 15, 4385–4406, https://doi.org/10.5194/amt-15-4385-2022, https://doi.org/10.5194/amt-15-4385-2022, 2022
Short summary
Short summary
Atmospheric chemistry plays a key role in the understanding of aerosol formation and air pollution. We designed chamber experiments for the characterization of secondary organic aerosol (SOA) from a biogenic precursor with inorganic seed. Our results highlight the advantages of a combination of online FIGAERO-CIMS and offline LC-Orbitrap MS analytical techniques to characterize the chemical composition of SOA in chamber studies.
Chuan Ping Lee, Mihnea Surdu, David M. Bell, Josef Dommen, Mao Xiao, Xueqin Zhou, Andrea Baccarini, Stamatios Giannoukos, Günther Wehrle, Pascal André Schneider, Andre S. H. Prevot, Jay G. Slowik, Houssni Lamkaddam, Dongyu Wang, Urs Baltensperger, and Imad El Haddad
Atmos. Meas. Tech., 15, 3747–3760, https://doi.org/10.5194/amt-15-3747-2022, https://doi.org/10.5194/amt-15-3747-2022, 2022
Short summary
Short summary
Real-time detection of both the gas and particle phase is needed to elucidate the sources and chemical reaction pathways of organic vapors and particulate matter. The Dual-EESI was developed to measure gas- and particle-phase species to provide new insights into aerosol sources or formation mechanisms. After characterizing the relative gas and particle response factors of EESI via organic aerosol uptake experiments, the Dual-EESI is more sensitive toward gas-phase analyes.
Martin I. Daily, Mark D. Tarn, Thomas F. Whale, and Benjamin J. Murray
Atmos. Meas. Tech., 15, 2635–2665, https://doi.org/10.5194/amt-15-2635-2022, https://doi.org/10.5194/amt-15-2635-2022, 2022
Short summary
Short summary
Mineral dust and particles of biological origin are important types of ice-nucleating particles (INPs) that can trigger ice formation of supercooled cloud droplets. Heat treatments are used to detect the presence of biological INPs in samples collected from the environment as the activity of mineral INPs is assumed unchanged, although not fully assessed. We show that the ice-nucleating ability of some minerals can change after heating and discuss how INP heat tests should be interpreted.
Jiyan Wu, Chi Yang, Chunyan Zhang, Fang Cao, Aiping Wu, and Yanlin Zhang
Atmos. Meas. Tech., 15, 2623–2633, https://doi.org/10.5194/amt-15-2623-2022, https://doi.org/10.5194/amt-15-2623-2022, 2022
Short summary
Short summary
We introduced an online method to simultaneously determine the content of inorganic salt ions and reactive oxygen species (ROS) in PM2.5 hour by hour. We verified the accuracy and precision of the instrument. And we got the daily changes in ROS and the main sources that affect ROS. This breakthrough enables the quantitative assessment of atmospheric particulate matter ROS at the diurnal scale, providing an effective tool to study sources and environmental impacts of ROS.
Virginia Vernocchi, Marco Brunoldi, Silvia G. Danelli, Franco Parodi, Paolo Prati, and Dario Massabò
Atmos. Meas. Tech., 15, 2159–2175, https://doi.org/10.5194/amt-15-2159-2022, https://doi.org/10.5194/amt-15-2159-2022, 2022
Short summary
Short summary
The performance of a mini inverted soot generator was investigated at a simulation chamber facility by studying the soot generated by ethylene and propane combustion, together with the number, size, optical properties, and EC / OC concentrations. Mass absorption coefficients and Ångström absorption exponents are compatible with the literature, with some differences. The characterization of MISG soot particles is fundamental to design and perform experiments in atmospheric simulation chambers.
Magdalena Vallon, Linyu Gao, Feng Jiang, Bianca Krumm, Jens Nadolny, Junwei Song, Thomas Leisner, and Harald Saathoff
Atmos. Meas. Tech., 15, 1795–1810, https://doi.org/10.5194/amt-15-1795-2022, https://doi.org/10.5194/amt-15-1795-2022, 2022
Short summary
Short summary
A LED-based light source has been constructed for the AIDA simulation chamber at the Karlsruhe Institute of Technology. It allows aerosol formation and ageing studies under atmospherically relevant illumination intensities and spectral characteristics at temperatures from –90 °C to 30 °C with the possibility of changing the photon flux and irradiation spectrum at any point. The first results of photolysis experiments with 2,3-pentanedione, iron oxalate and a brown carbon component are shown.
Danaël Cholleton, Émilie Bialic, Antoine Dumas, Pascal Kaluzny, Patrick Rairoux, and Alain Miffre
Atmos. Meas. Tech., 15, 1021–1032, https://doi.org/10.5194/amt-15-1021-2022, https://doi.org/10.5194/amt-15-1021-2022, 2022
Short summary
Short summary
While pollen impacts public health and the Earth’s climate, the identification of each pollen taxon remains challenging. In this context, a laboratory evaluation of the polarimetric light-scattering characteristics of ragweed, ash, birch and pine pollen, when embedded in ambient air, is here performed at two wavelengths. Interestingly, the achieved precision of the retrieved scattering matrix elements allows unequivocal light scattering characteristics of each studied taxon to be identified.
Kanishk Gohil and Akua A. Asa-Awuku
Atmos. Meas. Tech., 15, 1007–1019, https://doi.org/10.5194/amt-15-1007-2022, https://doi.org/10.5194/amt-15-1007-2022, 2022
Short summary
Short summary
This work develops a methodology and software to study and analyze the cloud-droplet-forming ability of aerosols with an aerodynamic aerosol classifier (AAC). This work quantifies the uncertainties in size-resolved measurements and subsequent uncertainties propagated to cloud droplet parameterizations. Lastly, we present the best practices for AAC cloud droplet measurement.
Yunqi Shao, Yu Wang, Mao Du, Aristeidis Voliotis, M. Rami Alfarra, Simon P. O'Meara, S. Fiona Turner, and Gordon McFiggans
Atmos. Meas. Tech., 15, 539–559, https://doi.org/10.5194/amt-15-539-2022, https://doi.org/10.5194/amt-15-539-2022, 2022
Short summary
Short summary
A comprehensive description and characterisation of the Manchester Aerosol Chamber (MAC) was conducted. The MAC has good temperature and relative humidity homogeneity, fast mixing times, and comparable losses of gases and particles with other chambers. The MAC's bespoke control system allows improved duty cycles and repeatable experiments. Moreover, the effect of contamination on performance was also investigated. It is highly recommended to regularly track the chamber's performance.
Dina Alfaouri, Monica Passananti, Tommaso Zanca, Lauri Ahonen, Juha Kangasluoma, Jakub Kubečka, Nanna Myllys, and Hanna Vehkamäki
Atmos. Meas. Tech., 15, 11–19, https://doi.org/10.5194/amt-15-11-2022, https://doi.org/10.5194/amt-15-11-2022, 2022
Short summary
Short summary
To study what is happening in the atmosphere, it is important to be able to measure the molecules and clusters present in it. In our work, we studied an artifact that happens inside a mass spectrometer, in particular the fragmentation of clusters. We were able to quantify the fragmentation and retrieve the correct concentration and composition of the clusters using our dual (experimental and theoretical) approach.
Kevin B. Fischer and Giuseppe A. Petrucci
Atmos. Meas. Tech., 14, 7565–7577, https://doi.org/10.5194/amt-14-7565-2021, https://doi.org/10.5194/amt-14-7565-2021, 2021
Short summary
Short summary
The viscosity of organic particles in atmospheric aerosol is sometimes correlated to bounce factor. It is generally accepted that more viscous particles will be more likely to bounce following acceleration toward and impaction on a surface. We demonstrate that use of multi-stage low-pressure impactors for this purpose may result in measurement artifacts that depend on chemical composition, particle size, and changing relative humidity. A hypothesis for the observed effect is presented.
Najin Kim, Yafang Cheng, Nan Ma, Mira L. Pöhlker, Thomas Klimach, Thomas F. Mentel, Ovid O. Krüger, Ulrich Pöschl, and Hang Su
Atmos. Meas. Tech., 14, 6991–7005, https://doi.org/10.5194/amt-14-6991-2021, https://doi.org/10.5194/amt-14-6991-2021, 2021
Short summary
Short summary
A broad supersaturation scanning CCN (BS2-CCN) system, in which particles are exposed to a range of supersaturation simultaneously, can measure a broad range of CCN activity distribution with a high time resolution. We describe how the BS2-CCN system can be effectively calibrated and which factors can affect the calibration curve. Intercomparison experiments between typical DMA-CCN and BS2-CCN measurements to evaluate the BS2-CCN system showed high correlation and good agreement.
Chenyang Bi, Jordan E. Krechmer, Manjula R. Canagaratna, and Gabriel Isaacman-VanWertz
Atmos. Meas. Tech., 14, 6551–6560, https://doi.org/10.5194/amt-14-6551-2021, https://doi.org/10.5194/amt-14-6551-2021, 2021
Short summary
Short summary
Calibration techniques have been recently developed to log-linearly correlate analyte sensitivity with CIMS operating conditions particularly for compounds without authentic standards. In this work, we examine the previously ignored bias in the log-linear-based calibration method and estimate an average bias of 30 %, with 1 order of magnitude for less sensitive compounds in some circumstances. A step-by-step guide was provided to reduce and even remove the bias.
Chuan Ping Lee, Mihnea Surdu, David M. Bell, Houssni Lamkaddam, Mingyi Wang, Farnoush Ataei, Victoria Hofbauer, Brandon Lopez, Neil M. Donahue, Josef Dommen, Andre S. H. Prevot, Jay G. Slowik, Dongyu Wang, Urs Baltensperger, and Imad El Haddad
Atmos. Meas. Tech., 14, 5913–5923, https://doi.org/10.5194/amt-14-5913-2021, https://doi.org/10.5194/amt-14-5913-2021, 2021
Short summary
Short summary
Extractive electrospray ionization mass spectrometry (EESI-MS) has been deployed for high throughput online detection of particles with minimal fragmentation. Our study elucidates the extraction mechanism between the particles and electrospray (ES) droplets of different properties. The results show that the extraction rate is likely affected by the coagulation rate between the particles and ES droplets. Once coagulated, the particles undergo complete extraction within the ES droplet.
Weimeng Kong, Stavros Amanatidis, Huajun Mai, Changhyuk Kim, Benjamin C. Schulze, Yuanlong Huang, Gregory S. Lewis, Susanne V. Hering, John H. Seinfeld, and Richard C. Flagan
Atmos. Meas. Tech., 14, 5429–5445, https://doi.org/10.5194/amt-14-5429-2021, https://doi.org/10.5194/amt-14-5429-2021, 2021
Short summary
Short summary
We present the design, modeling, and experimental characterization of the nano-scanning electrical mobility spectrometer (nSEMS), a recently developed instrument that probes particle physical properties in the 1.5–25 nm range. The nSEMS has proven to be extremely powerful in examining atmospheric nucleation and the subsequent growth of nanoparticles in the CERN CLOUD experiment, which provides a valuable asset to study atmospheric nanoparticles and to evaluate their impact on climate.
Jack M. Choczynski, Ravleen Kaur Kohli, Craig S. Sheldon, Chelsea L. Price, and James F. Davies
Atmos. Meas. Tech., 14, 5001–5013, https://doi.org/10.5194/amt-14-5001-2021, https://doi.org/10.5194/amt-14-5001-2021, 2021
Short summary
Short summary
Relative humidity (RH) and hygroscopicity play an important role in regulating the physical, chemical, and optical properties of aerosol. In this work, we develop a new method to characterize hygroscopicity using particle levitation. We levitate two droplets with an electrodynamic balance and measure their size with light-scattering methods using one droplet as a probe of the RH. We demonstrate highly accurate and precise measurements of the RH and hygroscopic growth of a range of samples.
Yuhan Yang, Dong Gao, and Rodney J. Weber
Atmos. Meas. Tech., 14, 4707–4719, https://doi.org/10.5194/amt-14-4707-2021, https://doi.org/10.5194/amt-14-4707-2021, 2021
Short summary
Short summary
Iron and copper are commonly found in ambient aerosols and have been linked to adverse health effects. We describe a relatively simple benchtop instrument that can be used to quantify these metals in aqueous solutions and verify the method by comparison with inductively coupled plasma mass spectrometry. The approach is based on forming light-absorbing metal–ligand complexes that can be measured with high sensitivity utilizing a long-path liquid waveguide capillary cell.
Stavros Amanatidis, Yuanlong Huang, Buddhi Pushpawela, Benjamin C. Schulze, Christopher M. Kenseth, Ryan X. Ward, John H. Seinfeld, Susanne V. Hering, and Richard C. Flagan
Atmos. Meas. Tech., 14, 4507–4516, https://doi.org/10.5194/amt-14-4507-2021, https://doi.org/10.5194/amt-14-4507-2021, 2021
Short summary
Short summary
We assess the performance of a highly portable mobility analyzer, the Spider DMA, in measuring ambient aerosol particle size distributions, with specific attention to its moderate sizing resolution (R=3). Long-term field testing showed excellent correlation with a conventional mobility analyzer (R=10) over the 17–500 nm range, suggesting that moderate resolution may be sufficient to obtain key properties of ambient size distributions, enabling smaller instruments and better counting statistics.
Silvia G. Danelli, Marco Brunoldi, Dario Massabò, Franco Parodi, Virginia Vernocchi, and Paolo Prati
Atmos. Meas. Tech., 14, 4461–4470, https://doi.org/10.5194/amt-14-4461-2021, https://doi.org/10.5194/amt-14-4461-2021, 2021
Short summary
Short summary
Experiments conducted inside confined artificial environments, such as atmospheric simulation chambers (ASCs), where atmospheric conditions and composition are controlled, can provide valuable information on bio-aerosol viability, dispersion, and impact. We focus here on the reproducible aerosolization and injection of viable microorganisms into an ASC, the first and crucial step of any experimental protocol to expose bio-aerosols to different atmospheric conditions.
Chenyang Bi, Jordan E. Krechmer, Graham O. Frazier, Wen Xu, Andrew T. Lambe, Megan S. Claflin, Brian M. Lerner, John T. Jayne, Douglas R. Worsnop, Manjula R. Canagaratna, and Gabriel Isaacman-VanWertz
Atmos. Meas. Tech., 14, 3895–3907, https://doi.org/10.5194/amt-14-3895-2021, https://doi.org/10.5194/amt-14-3895-2021, 2021
Short summary
Short summary
Measurement techniques that can achieve molecular characterizations are necessary to understand the differences of fate and transport within isomers produced in the atmospheric oxidation process. In this work, we develop an instrument to conduct isomer-resolved measurements of particle-phase organics. We assess the number of isomers per chemical formula in atmospherically relevant samples and examine the feasibility of extending the use of an existing instrument to a broader range of analytes.
Cited articles
Abe, K. and Saito, H: Characterization of t-butyl hydroperoxide toxicity in
cultured rat cortical neurones and astrocytes, Pharmacol. Toxicol., 83, 40–46, https://doi.org/10.1111/j.1600-0773.1998.tb01440.x, 1998.
Alía, M., Ramos, S., Mateos, R., Bravo, L., and Goya, L.: Response of
the antioxidant defense system to tert-butyl hydroperoxide and hydrogen
peroxide in a human hepatoma cell line (HepG2), J. Biochem. Mol. Toxic.,
19, 119–128, https://doi.org/10.1002/jbt.20061, 2005.
Berg, K. E., Clark, K. M., Li, X., Carter, E. M., Volckens, J., and Henry,
C. S.: High-throughput, semi-automated dithiothreitol (DTT) assays for
oxidative potential of fine particulate matter, Atmos. Environ., 222,
117132, https://doi.org/10.1016/j.atmosenv.2019.117132, 2020.
Breitner, S., Peters, A., Zareba, W., Hampel, R., Oakes, D., Wiltshire, J.,
Frampton, M. W., Hopke, P. K., Cyrys, J., Utell, M. J., Kane, C., Schneider,
A., and Rich, D. Q.: Ambient and controlled exposures to particulate air
pollution and acute changes in heart rate variability and repolarization,
Sci. Rep., 9, 1–12, https://doi.org/10.1038/s41598-019-38531-9, 2019.
Brown, R. A., Stevanovic, S., Bottle, S., and Ristovski, Z. D.: An instrument for the rapid quantification of PM-bound ROS: the Particle Into Nitroxide Quencher (PINQ), Atmos. Meas. Tech., 12, 23872401, https://doi.org/10.5194/amt-12-2387-2019, 2019.
Castro-Alférez, M., Polo-López, M., and Fernández-Ibáñez, P.: Intracellular mechanisms of solar water disinfection, Sci. Rep., 6, 1–10, https://doi.org/10.1038/srep38145, 2016.
Charrier, J. G. and Anastasio, C.: On dithiothreitol (DTT) as a measure of oxidative potential for ambient particles: evidence for the importance of soluble transition metals, Atmos. Chem. Phys., 12, 9321–9333, https://doi.org/10.5194/acp-12-9321-2012, 2012.
Chen, X., Zhong, Z., Xu, Z., Chen, L., and Wang, Y.: 2′,7′-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen
species measurement: Forty years of application and controversy, Free Radical
Res., 44, 587–604, https://doi.org/10.3109/10715761003709802, 2010.
Crobeddu, B., Aragao-Santiago, L., Bui, L. C., Boland, S., and Baeza
Squiban, A.: Oxidative potential of particulate matter 2.5 as predictive
indicator of cellular stress, Environ. Pollut., 230, 125–133,
https://doi.org/10.1016/j.envpol.2017.06.051, 2017.
Den Hartigh, L. J., Lamé, M. W., Ham, W., Kleeman, M. J., Tablin, F.,
and Wilson, D. W.: Endotoxin and polycyclic aromatic hydrocarbons in ambient
fine particulate matter from Fresno, California initiate human monocyte
inflammatory responses mediated by reactive oxygen species, Toxicol. In
Vitro, 24, 1993–2002, https://doi.org/10.1016/j.tiv.2010.08.017, 2010.
Dierickx, P. J., Van Nuffel, G., and Alvarez, I.: Glutathione protection
against hydrogen peroxide, tert-butyl hydroperoxide and diamide cytotoxicity
in rat hepatoma-derived Fa32 cells, Hum. Exp. Toxicol., 18, 627–633,
https://doi.org/10.1191/096032799678839482,1999.
Dikalov, S. I. and Harrison, D. G.: Methods for detection of mitochondrial
and cellular reactive oxygen species, Antioxid. Redox Sign., 20, 372–382, https://doi.org/10.1089/ars.2012.4886, 2014.
Dikalov, S. I., Polienko, Y. F., and Kirilyuk, I.: Electron Paramagnetic
Resonance Measurements of Reactive Oxygen Species by Cyclic Hydroxylamine
Spin Probes, Antioxid. Redox Sign., 28, 1433–1443, https://doi.org/10.1089/ars.2017.7396, 2018.
Doiron, D., de Hoogh, K., Probst-Hensch, N., Mbatchou, S., Eeftens, M., Cai,
Y., Schindler, C., Fortier, I., Hodgson, S., Gaye, A., Stolk, R., and
Hansell, A.: Residential air pollution and associations with wheeze and
shortness of breath in adults: A combined analysis of cross-sectional data
from two large European cohorts, Environ. Health Persp., 125, 1–10,
https://doi.org/10.1289/EHP1353, 2017.
Fang, T., Verma, V., Guo, H., King, L. E., Edgerton, E. S., and Weber, R. J.: A semi-automated system for quantifying the oxidative potential of ambient particles in aqueous extracts using the dithiothreitol (DTT) assay: results from the Southeastern Center for Air Pollution and Epidemiology (SCAPE), Atmos. Meas. Tech., 8, 471–482, https://doi.org/10.5194/amt-8-471-2015, 2015.
Fatemi, N., Sanati, M. H., Jamali Zavarehei, M., Ayat, H., Esmaeili, V.,
Golkar-Narenji, A., Zarabi, M., and Gourabi, H.: Effect of tertiary-butyl
hydroperoxide (TBHP)-induced oxidative stress on mice sperm quality and
testis histopathology, Andrologia, 45, 232–239.
https://doi.org/10.1111/j.1439-0272.2012.01335.x, 2013.
Gao, D., Fang, T., Verma, V., Zeng, L., and Weber, R. J.: A method for measuring total aerosol oxidative potential (OP) with the dithiothreitol (DTT) assay and comparisons between an urban and roadside site of water-soluble and total OP, Atmos. Meas. Tech., 10, 2821–2835, https://doi.org/10.5194/amt-10-2821-2017, 2017.
Gao, Y., Jiang, R., Qie, J., Chen, Y., Xu, D., Liu, W., and Gao, Q.: Studies
on the characteristic and activity of low-molecular fragments from zymosan,
Carbohyd. Polym., 90, 1411–1414, https://doi.org/10.1016/j.carbpol.2012.05.096, 2012.
Guidarelli, A., Cattabeni, F., and Cantoni, O.: Alternative mechanisms for
hydroperoxide-induced DNA single strand breakage, Free Radical Res., 26,
537–547, https://doi.org/10.3109/10715769709097825, 1997.
Helmke, R. J., Boyd, R. L., German, V. F., and Mangos, J. A.: From growth
factor dependence to growth factor responsiveness: The genesis of an
alveolar macrophage cell line, In Vitro Cell. Dev. B., 23, 567–574, https://doi.org/10.1007/BF02620974, 1987.
Holm, S. M., Balmes, J., Gillette, D., Hartin, K., Seto, E., Lindeman, D.,
Polanco, D., and Fong, E.: Cooking behaviors are related to household
particulate matter exposure in children with asthma in the urban East Bay
Area of Northern California, PLoS ONE, 13, 1–15, https://doi.org/10.1371/journal.pone.0197199, 2018.
Hu, S., Polidori, A., Arhami, M., Shafer, M. M., Schauer, J. J., Cho, A., and Sioutas, C.: Redox activity and chemical speciation of size fractioned PM in the communities of the Los Angeles-Long Beach harbor, Atmos. Chem. Phys., 8, 6439–6451, https://doi.org/10.5194/acp-8-6439-2008, 2008.
Huang, W., Zhang, Y., Zhang, Y., Zeng, L., Dong, H., Huo, P., Fang D., and
Schauer, J. J.: Development of an automated sampling-analysis system for
simultaneous measurement of reactive oxygen species (ROS) in gas and
particle phases: GAC-ROS, Atmos. Environ., 134, 18–26,
https://doi.org/10.1016/j.atmosenv.2016.03.038, 2016.
Ikeda, Y., Nakano, M., Ihara, H., Ito, R., Taniguchi, N., and Fujii, J.:
Different consequences of reactions with hydrogen peroxide and t-butyl
hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4, J.
Biochem., 149, 443–453, https://doi.org/10.1093/jb/mvq156, 2011.
Jaguin, M., Houlbert, N., Fardel, O., and Lecureur, V.: Polarization
profiles of human M-CSF-generated macrophages and comparison of M1-markers
in classically activated macrophages from GM-CSF and M-CSF origin, Cell.
Immunol., 281, 51–61, https://doi.org/10.1016/j.cellimm.2013.01.010, 2013.
Janssen, N. A. H., Strak, M., Yang, A., Hellack, B., Kelly, F. J.,
Kuhlbusch, T. A. J., Harrison, R. M., Brunekreef, B., Cassee, F. R.,
Steenhof, M., and Hoek, G.: Associations between three specific a-cellular
measures of the oxidative potential of particulate matter and markers of
acute airway and nasal inflammation in healthy volunteers, Occup. Environ.
Med., 72, 49–56, https://doi.org/10.1136/oemed-2014-102303, 2015.
Jeong, M. S., Yu, K. N., Chung, H. H., Park, S. J., Lee, A. Y., Song, M. R.,
Cho, M. H., and Kim, J. S.: Methodological considerations of electron spin
resonance spin trapping techniques for measuring reactive oxygen species
generated from metal oxide nanomaterials, Sci. Rep., 6, 1–10,
https://doi.org/10.1038/srep26347, 2016.
Jesch, N. K., Dörger, M., Enders, G., Rieder, G., Vogelmeier, C.,
Messmer, K., and Krombach, F.: Expression of inducible nitric oxide synthase
and formation of nitric oxide by alveolar macrophages: an interspecies
comparison, Environ. Health Persp., 105, Suppl. 5, 1297–1300,
https://doi.org/10.1289/ehp.97105s51297, 1997.
Kam, W., Ning, Z., Shafer, M. M., Schauer, J. J., and Sioutas, C.: Chemical
characterization and redox potential of coarse and fine particulate matter
(PM) in underground and ground-level rail systems of the Los Angeles Metro,
Environ. Sci. Technol., 45, 6769–6776, https://doi.org/10.1021/es201195e, 2011.
Karakatsani, A., Analitis, A., Perifanou, D., Ayres, J. G., Harrison, R. M.,
Kotronarou, A., Kavouras, I. G., Pekkanen, J., Hämeri, K., Kos, G. P.,
De Hartog, J. J., Hoek, G., and Katsouyanni, K.: Particulate matter air
pollution and respiratory symptoms in individuals having either asthma or
chronic obstructive pulmonary disease: A European multicentre panel study,
Environ. Health, 11, 1–16, https://doi.org/10.1186/1476-069X-11-75, 2012.
Klein, C. B., Su, L., Bowser, D., and Leszcynska, J.: Chromate-induced
epimutations in mammalian cells, Environ. Health Persp., 110, Suppl. 5,
739–743, https://doi.org/10.1289/ehp.02110s5739, 2002.
Klotz, L. O., Hou, X., and Jacob, C.: 1,4-naphthoquinones: From oxidative
damage to cellular and inter-cellular signaling, Molecules, 19, 14902–14918, https://doi.org/10.3390/molecules190914902, 2014.
Krombach, F., Münzing, S., Allmeling, A. M., Gerlach, J. T., Behr, J.,
and Dörger, M.: Cell size of alveolar macrophages: an interspecies
comparison, Environ. Health Persp., 105, Suppl. 5, 1261–1263,
https://doi.org/10.1289/ehp.97105s51261, 1997.
Kryston, T. B., Georgiev, A. B., Pissis, P., and Georgakilas, A. G.: Role of
oxidative stress and DNA damage in human carcinogenesis, Mutat. Res.-Fund. Mol. M., 711, 193–201, https://doi.org/10.1016/j.mrfmmm.2010.12.016, 2011.
Kučera, O., Endlicher, R., Roušar, T., Lotková, H., Garnol, T.,
Drahota, Z., and Červinková, Z.: The effect of tert-butyl
hydroperoxide-induced oxidative stress on lean and steatotic rat hepatocytes
in vitro, Oxid. Med. Cell. Longev., 2014, 752506, https://doi.org/10.1155/2014/752506, 2014.
Künzli, N., Mudway, I. S., Götschi, T., Shi, T., Kelly, F. J., Cook,
S., Burney, P., Forsberg, B., Gauderman, J. W., Hazenkamp, M. E., Heinrich,
J., Jarvis, D., Norbäck, D., Payo-Losa, F., Poli, A., Sunyer, J., and
Borm, P. J. A.: Comparison of oxidative properties, light absorbance, and
total and elemental mass concentration of ambient PM2.5 collected at 20
European sites, Environ. Health Persp., 114, 684–690,
https://doi.org/10.1289/ehp.8584, 2006.
Kuznetsov, A. V., Kehrer, I., Kozlov, A. V., Haller, M., Redl, H., Hermann,
M., Grimm, M., and Troppmair, J.: Mitochondrial ROS production under
cellular stress: Comparison of different detection methods, Anal. Bioanal.
Chem., 400, 2383–2390, https://doi.org/10.1007/s00216-011-4764-2, 2011.
Landkocz, Y., Ledoux, F., André, V., Cazier, F., Genevray, P., Dewaele,
D., Martin, P. J., Lepers, C., Verdin, A., Courcot, L., Boushina, S.,
Sichel, F., Gualtieri, M., Shirali, P., Courcot, D., and Billet, S.: Fine
and ultrafine atmospheric particulate matter at a multi-influenced urban
site: Physicochemical characterization, mutagenicity and cytotoxicity,
Environ. Pollut., 221, 130–140, https://doi.org/10.1016/j.envpol.2016.11.054, 2017.
Landreman, A. P., Shafer, M. M., Hemming, J. C., Hannigan, M. P., and
Schauer, J. J.: A macrophage-based method for the assessment of the reactive
oxygen species (ROS) activity of atmospheric particulate matter (PM) and
application to routine (daily-24 h) aerosol monitoring studies, Aerosol Sci.
Technol., 42, 946–957, https://doi.org/10.1080/02786820802363819, 2008.
Li, N., Xia, T., and Nel, A. E.: The role of oxidative stress in ambient
particulate matter-induced lung diseases and its implications in the
toxicity of engineered nanoparticles, Free Radical Bio. Med., 44,
1689–1699, https://doi.org/10.1016/j.freeradbiomed.2008.01.028, 2008.
Libalova, H., Milcova, A., Cervena, T., Vrbova, K., Rossnerova, A.,
Novakova, Z., Topinka, J., and Rossner, P.: Kinetics of ROS generation
induced by polycyclic aromatic hydrocarbons and organic extracts from
ambient air particulate matter in model human lung cell lines, Mutat. Res.-Gen. Tox. En., 827, 50–58, https://doi.org/10.1016/j.mrgentox.2018.01.006, 2018.
Lin, T. J., Hirji, N., Stenton, G. R., Gilchrist, M., Grill, B. J.,
Schreiber, A. D., and Befus, A. D.: Activation of macrophage CD8:
pharmacological studies of TNF and IL-1β production, J. Immunol.,
164, 1783–1792, https://doi.org/10.4049/jimmunol.164.4.1783, 2000.
Lopes, V. R., Sanchez-Martinez, C., Strømme, M., and Ferraz, N.: In vitro
biological responses to nanofibrillated cellulose by human dermal, lung and
immune cells: Surface chemistry aspect, Part. Fibre Toxicol., 14, 1–13,
https://doi.org/10.1186/s12989-016-0182-0, 2017.
Miljevic, B., Hedayat, F., Stevanovic, S., Fairfull-Smith, K. E., Bottle, S.
E., and Ristovski, Z. D.: To sonicate or not to sonicate PM filters:
Reactive oxygen species generation upon ultrasonic irradiation, Aerosol Sci.
Tech., 48, 1276–1284, https://doi.org/10.1080/02786826.2014.981330, 2014.
Møller, P., Jacobsen, N. R., Folkmann, J. K., Danielsen, P. H.,
Mikkelsen, L., Hemmingsen, J. G., Vesterdal, L. K., Forchhammer, L., Wallin,
H., and Loft, S.: Role of oxidative damage in toxicity of particulate, Free
Radical Res., 44, 1–46, https://doi.org/10.3109/10715760903300691, 2010.
Mudway, I. S., Duggan, S. T., Venkataraman, C., Habib, G., Kelly, F. J., and
Grigg, J.: Combustion of dried animal dung as biofuel results in the
generation of highly redox active fine particulates, Part. Fibre Toxicol.,
2, 1–11, https://doi.org/10.1186/1743-8977-2-6, 2005.
OECD/SIDS: Screening Information Data Set (SIDS) for High Production
Volume Chemicals, Organization for Economic Co-operation and Development, OECD Initial Assessment, IRPTC/UNEP, Volume 1, Part 2, 1995.
Øvrevik, J.: Oxidative potential versus biological effects: A review on
the relevance of cell-free/abiotic assays as predictors of toxicity from
airborne particulate matter, Int. J. Mol. Sci., 20, 4772,
https://doi.org/10.3390/ijms20194772, 2019.
Pieters, N., Plusquin, M., Cox, B., Kicinski, M., Vangronsveld, J., and
Nawrot, T. S.: An epidemiological appraisal of the association between heart
rate variability and particulate air pollution: A meta-analysis, Heart,
98, 1127–1135, https://doi.org/10.1136/heartjnl-2011-301505, 2012.
Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E.,
Krewski, D., and Godleski, J. J.: Cardiovascular Mortality and Long-Term
Exposure to Particulate Air Pollution: Epidemiological Evidence of General
Pathophysiological Pathways of Disease, Circulation, 109, 71–77,
https://doi.org/10.1161/01.CIR.0000108927.80044.7F, 2004.
Prasad, D., Ram, M. S., Sawhney, R. C., Ilavazhagan, G., and Banerjee, P.
K.: Mechanism of tert-butylhydroperoxide induced cytotoxicity in U-937 macrophages by alteration of mitochondrial function and generation of ROS, Toxicol. In Vitro, 21, 846–854, https://doi.org/10.1016/j.tiv.2007.02.007, 2007.
Puthussery, J. V., Zhang, C., and Verma, V.: Development and field testing of an online instrument for measuring the real-time oxidative potential of ambient particulate matter based on dithiothreitol assay, Atmos. Meas. Tech., 11, 5767–5780, https://doi.org/10.5194/amt-11-5767-2018, 2018.
Rao, X., Zhong, J., Brook, R. D., and Rajagopalan, S.: Effect of particulate
matter air pollution on cardiovascular oxidative stress pathways, Antioxid.
Redox Sign., 28, 797–818, https://doi.org/10.1089/ars.2017.7394, 2018.
Reuter, S., Gupta, S. C., Chaturvedi, M. M., and Aggarwal, B. B.:
Oxidative stress, inflammation, and cancer: How are they linked?, Free
Radical Bio. Med., 49, 1603–1616, https://doi.org/10.1016/j.freeradbiomed.2010.09.006, 2010.
Riojas-Rodríguez, H., Escamilla-Cejudo, J. A., González-Hermosillo,
J. A., Téllez-Rojo, M. M., Vallejo, M., Santos-Burgoa, C., and
Rojas-Bracho, L.: Personal PM2.5 and CO exposures and heart rate
variability in subjects with known ischemic heart disease in Mexico City, J.
Expo. Sci. Env. Epid., 16 131–137, https://doi.org/10.1038/sj.jea.7500453, 2006.
Rosenkranz, A. R., Schmaldienst, S., Stuhlmeier, K. M., Chen, W., Knapp, W.,
and Zlabinger, G. J.: A microplate assay for the detection of oxidative
products using 2′,7′-dichlorofluorescin-diacetate, J. Immunol. Methods, 156, 39–45, https://doi.org/10.1016/0022-1759(92)90008-h, 1992.
Rossner, P., Libalova, H., Vrbova, K., Cervena, T., Rossnerova, A.,
Elzeinova, F., Milcova, A., Novakova, Z., and Topinka, J.: Genotoxicant
exposure, activation of the aryl hydrocarbon receptor, and lipid
peroxidation in cultured human alveolar type II A549 cells, Mutat. Res.-Gen. Tox. En., 853, 503173, https://doi.org/10.1016/j.mrgentox.2020.503173, 2020.
Roux, C., Jafari, S. M., Shinde, R., Duncan, G., Cescon, D. W., Silvester,
J., Chu, M. F., Hodgson, K., Berger, T., Wakeham, A., Palomero, L.,
Garcia-Valero, M., Pujana, M. A., Mak, T. W., McGaha, T. L., Cappello, P.,
and Gorrini, C.: Reactive oxygen species modulate macrophage
immunosuppressive phenotype through the up-regulation of PD-L1, P. Natl. Acad. Sci. USA, 116, 4326–4335, https://doi.org/10.1073/pnas.1819473116, 2019.
Sameenoi, Y., Koehler, K., Shapiro, J., Boonsong, K., Sun, Y., Collett Jr.,
J., Volckens, J., and Henry, C. S.: Microfluidic electrochemical sensor for
on-line monitoring of aerosol oxidative activity, J. Am. Chem. Soc., 134, 10562–10568, https://doi.org/10.1021/ja3031104, 2012.
Shang, Y., Zhang, L., Jiang, Y., Li, Y., and Lu, P.: Airborne quinones
induce cytotoxicity and DNA damage in human lung epithelial A549 cells: The
role of reactive oxygen species, Chemosphere, 100, 42–49,
https://doi.org/10.1016/j.chemosphere.2013.12.079, 2014.
Shinkai, Y., Iwamoto, N., Miura, T., Ishii, T., Cho, A. K., and Kumagai, Y.:
Redox cycling of 1,2-naphthoquinone by thioredoxin1 through Cys32 and Cys35
causes inhibition of its catalytic activity and activation of ASK1/p38
signaling, Chem. Res. Toxicol., 25(6), 1222–1230,
https://doi.org/10.1021/tx300069r, 2012.
Slamenova, D., Kozics, K., Hunakova, L., Melusova, M., Navarova, J., and
Horvathova, E.: (2013). Comparison of biological processes induced in HepG2
cells by tert-butyl hydroperoxide (t-BHP) and hydroperoxide (H2O2): The influence of carvacrol, Mutat. Res.-Gen. Tox. En., 757, 15–22, https://doi.org/10.1016/j.mrgentox.2013.03.014, 2013.
Steenhof, M., Gosens, I., Strak, M., Godri, K. J., Hoek, G., Cassee, F. R.,
Mudway, I. S., Kelly, F. J., Harrison, R. M., Lebret, E., Brunekreef, B.,
Janssen, N. A. H., and Pieters, R. H. H.: In vitro toxicity of particulate
matter (PM) collected at different sites in the Netherlands is associated
with PM composition, size fraction and oxidative potential – the RAPTES
project, Part. Fibre Toxicol., 8, 1–15,
https://doi.org/10.1186/1743-8977-8-26, 2011.
Sun, J., Wang, S., Zhao, D., Hun, F. H., Weng, L., and Liu, H.:
Cytotoxicity, permeability, and inflammation of metal oxide nanoparticles in
human cardiac microvascular endothelial cells: Cytotoxicity, permeability,
and inflammation of metal oxide nanoparticles, Cell Biol. Toxicol., 27,
333–342, https://doi.org/10.1007/s10565-011-9191-9, 2011.
Sung, S. S. J., Nelson, R. S., and Silverstein, S. C.: Yeast mannans inhibit
binding and phagocytosis of zymosan by mouse peritoneal macrophages, J. Cell
Biol., 96, 160–166, https://doi.org/10.1083/jcb.96.1.160, 1983.
Thayyullathil, F., Chathoth, S., Hago, A., Patel, M., and Galadari, S.:
Rapid reactive oxygen species (ROS) generation induced by curcumin leads to
caspase-dependent and -independent apoptosis in L929 cells, Free Radical
Bio. Med., 45, 1403–1412, https://doi.org/10.1016/j.freeradbiomed.2008.08.014, 2008.
Thomas, C. A., Li, Y., Kodama, T., Suzuki, H., Silverstein, S. C., and El Khoury, J.: Protection from lethal Gram-positive infection by macrophage scavenger receptor–dependent phagocytosis, J. Exp. Med., 191, 147–156, https://doi.org/10.1084/jem.191.1.147, 2000.
Tsai, J. H., Chen, S. J., Huang, K. L., Lin, T. C., Chaung, H. C., Chiu, C.
H., Chiu, J. Y., Lin, C. C., and Tsai, P. Y.: PM, carbon, PAH, and
particle-extract-induced cytotoxicity Emissions from a diesel generator
fueled with waste-edible-oil-biodiesel, Aerosol Air Qual. Res., 12,
843–855, https://doi.org/10.4209/aaqr.2012.07.0181, 2012.
Underhill, D. M.: Macrophage recognition of zymosan particles, J. Endotoxin
Res., 9, 176–180, https://doi.org/10.1179/096805103125001586, 2003.
Venkatachalam, G., Arumugam, S., and Doble, M.: Synthesis, Characterization,
and Biological Activity of Aminated Zymosan, ACS Omega, 5, 15973–15982,
https://doi.org/10.1021/acsomega.0c01243, 2020.
Venkatachari, P. and Hopke, P. K.: Development and laboratory testing of an
automated monitor for the measurement of atmospheric particle-bound reactive
oxygen species (ROS), Aerosol Sci. Technol., 42, 629–635,
https://doi.org/10.1080/02786820802227345, 2008.
Verma, V., Ning, Z., Cho, A. K., Schauer, J. J., Shafer, M. M., and Sioutas,
C.: Redox activity of urban quasi-ultrafine particles from primary and
secondary sources, Atmos. Environ., 43, 6360–6368,
https://doi.org/10.1016/j.atmosenv.2009.09.019, 2009.
Vidrio, E., Phuah, C. H., Dillner, A. M., and Anastasio, C.: Generation of
hydroxyl radicals from ambient fine particles in a surrogate lung fluid
solution, Environ. Sci. Technol., 43, 922–927, https://doi.org/10.1021/es801653u, 2009.
Visentin, M., Pagnoni, A., Sarti, E., and Pietrogrande, M. C.: Urban
PM2.5 oxidative potential: Importance of chemical species and
comparison of two spectrophotometric cell-free assays, Environ. Pollut.,
219, 72–79, https://doi.org/10.1016/j.envpol.2016.09.047, 2016.
Vondráček, J., Pěnčíková, K., Neča, J., Ciganek, M., Grycová, A., Dvořák, Z., and Machala, M.: Assessment of the aryl hydrocarbon receptor-mediated activities of polycyclic aromatic hydrocarbons in a human cell-based reporter gene assay, Environ. Pollut., 220, 307–316, https://doi.org/10.1016/j.envpol.2016.09.064, 2017.
Wan, C. P., Myung, E., and Lau, B. H. S.: An automated micro-fluorometric
assay for monitoring oxidative burst activity of phagocytes, J. Immunol.
Methods, 159, 131–138, https://doi.org/10.1016/0022-1759(93)90150-6, 1993.
Wan, R., Mo, Y., Feng, L., Chien, S., Tollerud, D. J., and Zhang, Q.: DNA
damage caused by metal nanoparticles: Involvement of oxidative stress and
activation of ATM, Chem. Res. Toxicol., 25, 1402–1411,
https://doi.org/10.1021/tx200513t, 2012.
Wang, D., Pakbin, P., Shafer, M. M., Antkiewicz, D., Schauer, J. J., and
Sioutas, C.: Macrophage reactive oxygen species activity of water-soluble
and water-insoluble fractions of ambient coarse, PM2.5 and ultrafine
particulate matter (PM) in Los Angeles, Atmos.Environ., 77, 301–310,
https://doi.org/10.1016/j.atmosenv.2013.05.031, 2013.
Wang, Y., Puthussery, J. V., Yu, H., and Verma, V.: Synergistic and
antagonistic interactions among organic and metallic components of the
ambient particulate matter (PM) for the cytotoxicity measured by Chinese
hamster ovary cells, Sci. Total Environ., 736, 139511,
https://doi.org/10.1016/j.scitotenv.2020.139511, 2020.
Wang, Z., Li, N., Zhao, J., White, J. C., Qu, P., and Xing, B.: CuO
nanoparticle interaction with human epithelial cells: Cellular uptake,
location, export, and genotoxicity, Chem. Res. Toxicol., 25, 1512–1521,
https://doi.org/10.1021/tx3002093, 2012.
Wragg, F. P. H., Fuller, S. J., Freshwater, R., Green, D. C., Kelly, F. J., and Kalberer, M.: An automated online instrument to quantify aerosol-bound reactive oxygen species (ROS) for ambient measurement and health-relevant aerosol studies, Atmos. Meas. Tech., 9, 4891–4900, https://doi.org/10.5194/amt-9-4891-2016, 2016.
Wu, J., Zhong, T., Zhu, Y., Ge, D., Lin, X., and Li, Q.: Effects of
particulate matter (PM) on childhood asthma exacerbation and control in
Xiamen, China, BMC Pediatr., 19, 1–11, https://doi.org/10.1186/s12887-019-1530-7, 2019.
Xiong, Q., Yu, H., Wang, R., Wei, J., and Verma, V.: Rethinking
Dithiothreitol-Based Particulate Matter Oxidative Potential: Measuring
Dithiothreitol Consumption versus Reactive Oxygen Species Generation,
Environ. Sci. Technol., 51, 6507–6514, https://doi.org/10.1021/acs.est.7b01272, 2017.
Xu, F., Shi, X., Qiu, X., Jiang, X., Fang, Y., Wang, J., Hu, D. and Zhu, T.:
Investigation of the chemical components of ambient fine particulate matter
(PM2.5) associated with in vitro cellular responses to oxidative stress and inflammation, Environ. Int., 136, 105475, https://doi.org/10.1016/j.envint.2020.105475, 2020.
Yang, B. Y., Guo, Y., Morawska, L., Bloom, M. S., Markevych, I., Heinrich,
J., Dharmage, S. C., Knibbs, L. D., Lin, S., Yim, S. H. L., Chen, G., Li,
S., Zeng, X. W., Liu, K. K., Hu, L. W., and Dong, G. H.: Ambient PM1 air
pollution and cardiovascular disease prevalence: Insights from the 33
Communities Chinese Health Study, Environ. Int., 123, 310–317,
https://doi.org/10.1016/j.envint.2018.12.012, 2019.
Yang, M., Ahmed, H., Wu, W., Jiang, B., and Jia, Z.: Cytotoxicity of Air
Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and
Redox Signaling, BioMed Res. Int., 2018, 9523968, https://doi.org/10.1155/2018/9523968, 2018.
Yu, H., Puthussery, J. V., and Verma, V.: A semi-automated multi-endpoint
reactive oxygen species activity analyzer (SAMERA) for measuring the
oxidative potential of ambient PM2.5 aqueous extracts, Aerosol Sci.
Technol., 54, 304–320, https://doi.org/10.1080/02786826.2019.1693492, 2019.
Yu, H., Wei, J., Cheng, Y., Subedi, K., and Verma, V.: Synergistic and
Antagonistic Interactions among the Particulate Matter Components in
Generating Reactive Oxygen Species Based on the Dithiothreitol Assay,
Environ. Sci. Technol., 52, 2261–2270, https://doi.org/10.1021/acs.est.7b04261, 2018.
Zhou, J., Bruns, E. A., Zotter, P., Stefenelli, G., Prévôt, A. S. H., Baltensperger, U., El-Haddad, I., and Dommen, J.: Development, characterization and first deployment of an improved online reactive oxygen species analyzer, Atmos. Meas. Tech., 11, 65–80, https://doi.org/10.5194/amt-11-65-2018, 2018.
Zmirou, D., Gauvin, S., Pin, I., Momas, I., Just, J., Sahraoui, F., Moullec,
Y. L., Bremont, F., Cassadou, S., Albertini, M., Lauvergne, N., Chiron, M.,
and Labbe, A.: Five epidemiological studies on transport and asthma:
objectives, design and descriptive results, J. Expo. Sci. Env. Epid., 12, 186–196, https://doi.org/10.1038/sj.jea.7500217, 2002.
Short summary
Oxidative potential (OP) of particulate matter (PM) is an important indicator of PM toxicity. However, no automated instrument has ever been developed to provide a rapid high-throughput analysis of cell-based OP measurements. Here, we developed a semi-automated instrument, the first of its kind, for measuring oxidative potential using rat alveolar cells. We also developed a dataset on the intrinsic cellular OP of several compounds commonly known to be present in ambient PM.
Oxidative potential (OP) of particulate matter (PM) is an important indicator of PM toxicity....
